Vaccination against malignant melanoma using bcg and/or...

A - Human Necessities – 61 – K

Patent

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A61K 39/02 (2006.01) A61K 39/002 (2006.01) A61K 39/12 (2006.01)

Patent

CA 2564115

The present invention relates to a vaccination which reduces the risk to contract melanoma to about half to third and moreover, within a five year period post diagnosis of malignant melanoma the risk to die is reduced to about half as compared to the non-vaccinated individuals. Beyond its effect on melanoma, the vaccination of the invention also may have protective effects against some other malignancies such as cancers of bladder, breast, esophagus, and kidney, against sarcomas and lymphomas, and against a multitude of micro- organisms which can induce severe and lethal infections or allergies. The present invention relates also to the use the yellow fever vaccine for the prophylactic vaccination against a malignancy, in particular melanoma, to the use of some other licensed vaccinations for the prophylactic vaccination against a malignancy, in particular melanoma, and to new synthetic vaccines which use the identified antigenic motifs.

L'invention concerne une vaccination réduisant le risque de contracter un mélanome environ de moitié à un tiers et de plus, dans une période de cinq ans suivant le diagnostic d'un mélanome malin, le risque de mortalité est réduit environ de moitié, par rapport à des individus non vaccinés. Au-delà de son effet sur le mélanome, la vaccination selon l'invention peut également présenter des effets protecteurs contre d'autres malignités, telles que des cancers de la vessie, du sein, de l'oesophage et des reins, contre des sarcomes et des lymphomes et contre une pluralité de micro-organismes pouvant induire des infections ou des allergies graves et mortelles. L'invention concerne également l'utilisation du vaccin contre la fièvre jaune, aux fins de vaccination prophylactique contre une malignité, notamment le mélanome, l'utilisation de quelques autres vaccinations brevetées destinées à la vaccination prophylactique contre une malignité, notamment le mélanome, et des vaccins synthétiques mettant en oeuvre les motifs antigéniques identifiés.

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