A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/145 (2006.01)
Patent
CA 2706619
H5N1 influenza viruses isolated from animals and humans since 2003 separate into distinct clades based on hemagglutinin amino acid sequences. According to the invention, multiple clades are used in influenza immunization. Thus there is a prime-boost immunization schedule where a subject receives a priming dose of a first clade of H5 influenza A virus and a boosting dose of a second clade of H5 influenza A virus. There is also an immunogenic composition comprising hemagglutinin antigens from more than one clade of H5 influenza A virus.
L'invention concerne les virus de la grippe A H5N1 isolés d'animaux et d'êtres humains depuis 2003 séparés en clades distincts sur la base de séquences d'acides aminés de l'hémagglutinine. Selon l'invention, de multiples clades sont utilisés dans l'immunisation contre la grippe. Ainsi, il existe un programme d'immunisation de type sensibilisation-rappel suivant lequel un sujet reçoit une dose de sensibilisation d'un premier clade du virus de la grippe A H5 et une dose de rappel d'un second clade du virus de la grippe A H5. L'invention concerne également une composition immunogène comprenant des antigènes de l'hémagglutinine provenant de plus d'un clade du virus de la grippe A H5.
Podda Audino
Rappuoli Rino
Borden Ladner Gervais Llp
Novartis Ag
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