Vaccination with peptide of mhc class ii molecules for...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) C07K 14/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2152075

The present invention provides immunogenic oligopeptides derived from the major histocompatibility complex (MHC) glycoprotein protein sequences for use in compositions and methods for the treatment, prevention and diagnosis of deleterious immune responses, such as autoimmunity and allergies. The peptides are capable of inducing an immune response against glycoproteins encoded MHC alleles associated with the target disease. In preferred embodiments the peptides of the invention are derived from hypervariable region of the .beta. chain of an MHC Class II molecule associated with the deleterious immune response.

La présente invention se rapporte à des oligopeptides immunogènesdérivés de séquences protéiques de la glycoprotéine du complexe majeur d'histocompatibilité (MHC), et devant être utilisés dans des compositions et des procédés destinés au traitement, à la prévention et au diagnostique de réponses immunitaires délétères, telles que l'autoimmunité et les allergies. Ces peptides sont capables d'induire une réponse immunitaire contre les glycoprotéines codées par des allèles de MHC associés à la maladie ciblée. Selon des modes de réalisation préférés, les peptides de l'invention sont dérivés de la région hypervariable de la chaîne beta d'une molécule de classe II de MHC associée à la réponse immunitaire délétère.

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