Vaccination with peptide of mhc class ii molecules for...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/74 (2006.01) A61K 39/00 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223714

The present invention provides immunogenic oligopeptides derived from the Major Histocompatibility Complex (MHC) glycoprotein protein sequences for use in compositions and methods for the treatment, prevention and diagnosis of deleterious immune responses, such as autoimmunity and allergies. The peptides are capable of inducing an immune response against glycoproteins encoded MHC alleles associated with the target disease. In preferred embodiments the peptides of the invention are derived from a hypervariable region of the .beta. chain of an MHC Class II molecule associated with the deleterious immune response.

La présente invention concerne des oligopeptides immunogènes dérivés des séquences de protéines de glycoprotéines du Complexe Majeur d'Histocompatibilité (CMH), lesquels oligopeptides sont destinés à des compositions et à des procédés de traitement, de prévention et de diagnostic de réponses immunes délétères, tel que l'auto-immunité et les allergies. Ces peptides sont capables d'induire une réponse immune contre des allèles du CMH codés par des glycoprotéines et associés à la maladie cible. Dans les modes de réalisation préférés, les peptides décrits dans la présente invention sont dérivés d'une région hypervariable de la chaîne .beta. d'une molécule du CMH de classe II associée à la réponse immune délétère.

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