A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/275 (2006.01) A61P 33/02 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2742049
The invention provides methods for stimulating an immune response to an antigen in a subject comprising administering to a subject in need thereof a live, modified, and / or recombinant replication- impaired or non-replicating poxvirus comprising the antigen in an amount sufficient to stimulate the immune response, wherein the virus is administered by mechanical disruption of the epidermis. The invention further provides kits comprising such viruses and epidermal disruption devices.
La présente invention concerne des procédés de stimulation dune réponse immunitaire à un antigène chez un sujet, qui comprennent ladministration à un sujet le nécessitant dun poxvirus non réplicant ou à réplication déficiente vivant, modifié et/ou recombinant, qui comprend lantigène en une quantité suffisante pour stimuler la réponse immunitaire, le virus étant administré par rupture mécanique de lépiderme. Linvention concerne en outre des kits comprenant ces virus et des dispositifs de rupture épidermique.
Kupper Thomas S.
Liu Luzheng Lisa
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Kupper Thomas S.
Liu Luzheng
The Brigham And Women's Hospital Inc.
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