Vaccine

Details Vaccine Vaccine

C - Chemistry, Metallurgy

07

K

C07K 14/025 (2006.01) A61K 39/385 (2006.01) A61K 48/00 (2006.01) C12N 15/86 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2384723

The invention relates to a carrier for introduction of a substance into cells, comprising a major capsid protein L1 of human papillomavirus (HPV-L1 protein) which has been intentionally modified to remove type-specific epitope(s) causing production of neutralising antibodies. The invention also includes an oligo- or polynucleotide coding for said carrier, vaccines comprising said carrier or said oligo- or polynucleotide, as well as methods of using the carrier or the oligo- or polynucleotide in vaccination against infections of human papillomavirus, or against development of consequences of such an infection, or against development of certain cancers.

La présente invention concerne un porteur destiné à introduire une substance dans des cellules, qui comprend une protéine L1 de capside principale de papillomavirus humain (HPV-L1) qui a été intentionnellement modifiée de façon à retirer l'épitope (les épitopes) de type spécifique qui entraînent la production d'anticorps de neutralisation. Cette invention concerne aussi un oligonucléotide ou un polynucléotide codant pour ce porteur, des vaccins comprenant ce porteur, cet oligonucléotide ou ce polynucléotide, de même que des techniques de vaccination contre des infections à papillomavirus humain, ou contre les conséquences d'une telle infection ou encore contre le développement de certains cancers.

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