A - Human Necessities
61
K
A61K 39/275 (2006.01) A61K 39/00 (2006.01) A61K 39/015 (2006.01) A61K 39/04 (2006.01) A61K 39/12 (2006.01) C12N 7/00 (2006.01) C12N 15/86 (2006.01) C12N 15/863 (2006.01)
Patent
CA 2467486
The present invention relates to a fowlpox virus genome which has modifications in one or more wild-type FPV genes. The present invention also relates to a viral particle comprising such a genome and its use to deliver a nucleotide of interest (NOI) to a target cell. The present invention also relates to vaccination methods, particularly a method which comprises administering a priming composition (which comprises a first non-replicating viral vector) and a boosting composition (which comprises a second non- replicating viral vector) to a subject to treat and/or prevent a disease.
L'invention concerne un génome du virus de la variole aviaire (fowlpox) qui comporte des modifications dans un ou plusieurs des gènes FPV de type sauvage. L'invention concerne par ailleurs une particule virale qui contient un tel génome, ainsi que son utilisation pour introduire un nucléotide étudié (NOI) dans une cellule cible. De plus, l'invention concerne des méthodes de vaccination, en particulier une méthode qui consiste à administrer à un sujet une composition de sensibilisation active primaire (qui contient un vecteur viral de non réplication) et une composition stimulante (qui contient un second vecteur viral de non réplication) dans un but thérapeutique ou prophylactique.
Anderson Richard
Gilbert Sarah
Hill Adrian
Laidlaw Stephen
Skinner Mike
Isis Innovation Limited
Sim & Mcburney
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