A - Human Necessities
61
K
A61K 39/095 (2006.01) C07H 13/00 (2006.01)
Patent
CA 2654709
The present invention relates to the field of neisserial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to processes of making novel engineered meningococcal strains which are more suitable for the production of neisserial, in particular meningococcal, outer- membrane vesicle (or bleb) vaccines. Advantageous processes and vaccine products are also described based on the use of novel LOS subunit or meningococcal outer-membrane vesicle (or bleb) vaccines which have been rendered safer and more effective for use in human subjects.
La présente invention concerne le domaine de compositions vaccinales anti-neisseria, leur fabrication et leur utilisation en médecine. Plus particulièrement, elle concerne des procédures pour fabriquer de nouvelles souches de méningocoques modifiées qui sont plus appropriées pour la production de vaccins de vésicule de membrane externe (ou pustule) anti-neisseria, en particulier anti-méningocoques. L'invention concerne également des procédures et des vaccins avantageux basés sur l'utilisation d'une nouvelle sous-unité LOS ou de vaccins à vésicule de membrane externe (ou pustule) de méningocoques qui ont été rendus plus sûrs et plus efficaces pour une utilisation chez des sujets humains.
Devos Nathalie
Feron Christiane
Poolman Jan
Weynants Vincent
Glaxosmithkline Biologicals Sa
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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