Vaccine

Details Vaccine Vaccine

A - Human Necessities

61

K

A61K 39/12 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2708718

A component for a HIV vaccine comprising: a) an immunogenic fusion protein comprising Nef or an immunogenic fragment or derivative thereof, and p17 Gag and/or p24 Gag or immunogenic fragments or derivatives thereof, wherein when both p 17 and p24 Gag are present there is at least one HIV antigen or immunogenic fragment between them, and b) a stabilising agent selected from the group comprising or consisting of monothioglycerol, cysteine, N-acetyl cysteine or mixtures thereof. The invention also extends to HIV vaccines comprising the same and use in treatment/prevention of HIV.

Constituant de vaccin anti-VIH comprenant: (a) une protéine de fusion immunogène comprenant Nef ou son fragment immunogène ou son dérivé et p17 Gag et/ou p24 Gag ou leurs fragments immunogènes ou leurs dérivés, au moins un antigène ou un fragment immunogène de VIH étant placé entre p17 et p24 Gag, dans le cas de la présence de ces derniers; (b) un agent stabilisant sélectionné dans le groupe consistant en monothioglycérol, cystéine, N-acétyl cystéine ou leurs mélanges. L'invention concerne également des vaccins anti-VIH contenant ledit constituant, ainsi que l'utilisation desdits vaccins pour la prophylaxie et le traitement du VIH.

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