Vaccine adjuvant

Details Vaccine adjuvant Vaccine adjuvant

A - Human Necessities

61

K

167/129

A61K 39/39 (2006.01) A61K 9/00 (2006.01)

Patent

CA 1338618

An adjuvant for potentiating the immunogenicity of an antigen, suitable for manufacture on a commercial scale, is an emulsion having oily particles dispersed in a continuous aqueous phase, which emulsion comprises: an emulsion-forming amount of a non-toxic tetra-polyol or polyoxyethylene-polyoxypropylene (POP-POE) block polymer; optionally, an emulsion-forming amount of a non-toxic metabolizable oil; optionally, an emulsion-stabilizing amount of a glycol ether-based surfactant; and an immunopotentiating amount of a glycopeptide; wherein substantially all of said oily particles have a diameter less than about 800 nm if a POP-POE block polymer is present.

582048

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