Vaccine against hepatitis b virus and human papilloma virus

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/295 (2006.01) A61K 39/002 (2006.01) A61K 39/12 (2006.01) A61K 39/125 (2006.01) A61K 39/245 (2006.01) A61K 39/25 (2006.01) A61K 39/29 (2006.01) A61K 39/39 (2006.01) A61P 31/20 (2006.01)

Patent

CA 2381047

Novel combined vaccine compositions are provided, comprising a hepatitis B viral antigen and a HPV antigen and optionally in addition one or more of the following: an EBV antigen, a hepatitis A antigen or inactivated attenuated virus, a herpes simplex viral antigen, a VZV antigen, a HCMV antigen, a Toxoplasma gondii antigen. The vaccine compositions are formulated with an adjuvant which is a preferential stimulator of TH1 cell response such as 3D- MPL and QS21.

L'invention concerne de nouvelles compositions de vaccin combiné, comprenant un antigène viral d'hépatite B et un antigène de papillomavirus, et en option, un ou plusieurs des composants suivants : un antigène de VEB, un antigène ou un virus inactivé atténué d'hépatite A, un antigène d'herpès simplex, un antigène de VZV, un antigène de HCMV, un antigène de toxoplasme. La formulation de ces compositions de vaccin comprend un adjuvant qui est un stimulateur préférentiel de la réponse des cellules Th1 telles que 3D-MPL et QS21.

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