Vaccine against lipopolysaccharide core

Details Vaccine against lipopolysaccharide core Vaccine against lipopolysaccharide core

A - Human Necessities

61

B

A61B 5/055 (2006.01) A61K 39/02 (2006.01) A61K 39/108 (2006.01) A61K 39/112 (2006.01) A61K 39/40 (2006.01) A61K 51/00 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2289760

Complete core LPS (lacking O-polysaccharide side chains) from Gram-negative bacteria are incorporated into a vaccine typically in liposomes. The complete core of E. coli K 12 is particularly useful. Upon administration to a mammal the vaccine stimulates synthesis of antibodies which are cross-protective against smooth and rough forms of LPS from at least two different Gram- negative bacterial strains having different core structures.

Selon cette invention, on incorpore à un vaccin se présentant généralement sous forme de liposomes, des lipopolysaccharides (LPS) à noyau complet (dépourvus de chaînes latérales de O-polysaccharide) provenant de bactéries Gram négatif. Le noyau complet de E.coli K12 s'avère particulièrement utile. Lorsqu'on l'administre à un mammifère, ce vaccin stimule la synthèse d'anticorps qui assurent une protection croisée contre les formes lisses et rugueuses de LPS, à partir d'au moins deux souches bactériennes Gram négatif dotées de structures de noyaux différentes.

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