Vaccine against mycobacterial infections

Details Vaccine against mycobacterial infections Vaccine against mycobacterial infections

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 31/7088 (2006.01) A61K 35/28 (2006.01) A61K 39/04 (2006.01) A61P 31/06 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2190515

A naked nucleic acid construct comprising a coding sequence which encodes a mycobacterial stress protein or proline-rich antigen or an antigenically effective fragment thereof operably linked to a promoter capable of expressing the said coding sequence in a mammalian host cell is useful as a vaccine against a mycobacterial infection such as tuberculosis and leprosy.

Produit de recombinaison nu d'acide nucléique comprenant une séquence codante codant une protéine de stress mycobactérienne ou un antigène riche en proline ou un de ses fragments antigéniquement efficace lié à un promoteur capable d'exprimer ladite séquence codante chez une cellule hôte de mammifère. Ledit produit de recombinaison est efficace en tant que vaccin contre une infection mycobactérienne, telle que la tuberculose et la lèpre.

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