A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/12 (2006.01) A61K 39/295 (2006.01) A61P 31/14 (2006.01) C12N 15/863 (2006.01)
Patent
CA 2448796
The invention concerns in vivo and in vitro expression vectors comprising a polynucleotide coding for the structural protein E of the Nile fever virus or the WN virus, optionally associated with a polynucleotide coding for the pre-membrane protein prM and/or for the membrane protein M, in particular in the form coding for prM-M-E. Said in vivo expression vectors are incorporated in live vaccines. The in vivo expression vectors are used for producing in vitro proteins which can then be used in subunit vaccines. The invention also concerns multivalent vaccines comprising a vaccine constituent against the WN virus and a vaccine constituent against another pathogen. The invention is particular designed for horses, dogs, cats, cattle, pigs and birds.
L'invention concerne des vecteurs d'expression in vivo et in vitro comprenant un polynucléotide codant pour la protéine structurale E du virus de la fièvre du Nil ou virus WN, éventuellement associé à un polynucléotide codant pour la protéine de pré-membrane prM et/ou pour la protéine de membrane M, notamment sous la forme codant pour prM-M-E. Des vaccins vivants incorporent de tels vecteurs d'expression in vivo. Les vecteurs d'expression in vitro sont utilisés pour produire les protéines in vitro qui pourront ensuite être utilisées dans des vaccins de sous-unités. L'invention concerne aussi des vaccins multivalents comprenant un composant de vaccin contre le virus WN et un composant de vaccin contre un autre agent pathogène. L'invention vise en particulier les équins, les canins, les félins, les bovins, les porcins et les oiseaux.
Audonnet Jean-Christophe Francis
May Loosmore Sheena
Merial
Smart & Biggar
LandOfFree
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