Vaccine and method for prophylaxis and treatment of...

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A61K 39/00 (2006.01)

Patent

CA 1136042

ABSTRACT OF THE DISCLOSURE The vaccine for prophylaxis and treatment of trichopyto- sis caused by Trichophyton mentagrophytes comprises a suspen- sion of microconidia of the immunogenic Trichophyton menta- grophytes strain No. 135/1963 in a physiological solution with pH of 6.2-7.0 in an amount of 15-25 mln microconidia per 1 ml of the physiological solution having 8-25 mln of viable micro- conidia. A method for preparing the vaccine comprises growing the fungus culture Trichophyton mentagrophytes on a nutrient medium containing sources of carbon, nitrogen, biologically active compounds till an optimal accumulation of microconidia, separation of the resulting biomass, homogenization thereof to give a suspension of individual cells of the microorganism and drying of the resulting suspension. A method for prophylaxis and treatment of trichophytosis caused by the pathogenic microorganism Trichophyton menta- grophytes comprising intramuscular injection of said vaccine to animals at the inner side of thigh thereof in a dose of 1 to 4 ml twice at an interval of from 7 to 10 days.

329199

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