C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
167/136
C08B 37/00 (2006.01) A61K 39/09 (2006.01) C07K 16/12 (2006.01) C12P 19/26 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1154382
00014 VACCINE AND METHOD OF MAKING ABSTRACT OF THE DISCLOSURE Culturing Streptococcus agalactiae in a nutrient broth containing at least 10 g/l of glucose while maintaining the pH at 6-8 by the addition of alkaline material produces poly- saccharide antigen including a fraction having a molecular size from 8-11 x 105d. By employing a broth free from constituents having a molecular size above 105 , the antigens can be separated from the broth in high yield after harvesting the organisms. Vaccination of humans with Streptococcus agalactiae polysaccharide antigens having molecular sizes above 5 X 105 produces in selected individuals specific antibody levels above 200 µg/ml of anti- sera; globulins fractionated from such antisera contain most of the antibody and can be used for passive immunization.
333322
Goudreau Gage Dubuc
President And Fellows Of Harvard College
LandOfFree
Vaccine and method of making does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vaccine and method of making, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaccine and method of making will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1107460