Vaccine and method therefor

Details Vaccine and method therefor Vaccine and method therefor

C - Chemistry, Metallurgy

07

K

C07K 14/235 (2006.01) A61K 39/00 (2006.01) A61K 39/10 (2006.01) A61K 39/385 (2006.01) C12N 1/00 (2006.01) C12N 1/20 (2006.01) C12N 7/04 (2006.01) C12N 7/06 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2075711

A detoxified B. pertussis toxin or antigenic preparation is described, which is characterized by stability to reversion to toxicity upon storage at 4-8 °C and at temperatures above 23 °C. Also provided are methods for producing detoxified pertussis toxin and vaccines containing same.

On décrit une toxine de B. pertussis détoxifiée ou une préparation antigénique caractérisée par une stabilité empêchant la réversion à la toxicité lors du stockage à 4-8 °C et à des températures supérieures à 23 °C. On présente également des procédés permettant d'obtenir la toxine de pertussis détoxifiée et des vaccins la contenant.

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