Vaccine and serum for endotoxin associated disease and...

Details Vaccine and serum for endotoxin associated disease and... Vaccine and serum for endotoxin associated disease and...

A - Human Necessities

61

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167/135, 167/139

A61K 39/112 (2006.01) A61K 39/02 (2006.01) A61K 39/39 (2006.01) A61K 39/40 (2006.01) C07K 16/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1263306

ABSTRACT A combination vaccine, with methods of prep- aration and treatment, for protection against Gram negative bacterial diseases. The vaccine includes a killed suspension of a bacterial mutant from the taxonomic family Enterobacteriaceae, a B-lymphocyte proliferating immune modulator, and a protein and lipid binding adjuvant. A hyperimmune serum for treating diseased animals is prepared by vaccinating a donor animal with the combination vaccine and then preparing clot serum containing antigen specific antibodies. The mutant is ATCC No. 53000 and is produced by ionizing radiation of Salmonella enteritidis. The immune modula- tor is a detoxified extract of lipopolysaccharide and is useful with many antigens to enhance primary immune response.

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