C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/74 (2006.01) A61K 39/02 (2006.01) A61K 39/09 (2006.01) A61K 39/095 (2006.01) A61K 39/102 (2006.01) A61K 39/104 (2006.01) A61K 39/116 (2006.01) A61K 39/118 (2006.01) A61K 39/295 (2006.01) C07K 14/195 (2006.01) C07K 14/21 (2006.01) C07K 14/22 (2006.01) C07K 14/285 (2006.01) C12N 1/21 (2006.01) C12N 15/31 (2006.01) C12N 15/67 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2380840
The present invention relates to an immuno-protective and non-toxic Gram- negative bleb vaccine suitable for paedi- atric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
L'invention concerne un vaccin immunoprotecteur et non toxique produit à partir des bulles de la membrane externe ( </= bleb >/= ), convenant pour les applications pédiatriques. Les souches gram-négatives produisant ces bulles comprennent par exemple <i>N. meningitidis, M. catarrhalis</i> et <i>H. influenzae</i>. Ces vaccins sont améliorés au moyen d'une ou de plusieurs modifications génétiques du chromosome de la bactérie, ces modifications produisant notamment une régulation positive des antigènes protecteurs et une régulation négative des antigènes non protecteurs immunodominants, ainsi qu'une détoxication de la portion lipidique A des LPS.
Berthet Francois-Xavier Jacques
Dalemans Wilfried L. J.
Denoel Philippe
Dequesne Guy
Feron Christiane
Borden Ladner Gervais Llp
Smithkline Beecham Biologicals S.a.
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