Vaccine composition

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/21 (2006.01) A61K 48/00 (2006.01) C07K 14/02 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C12N 15/89 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2447616

Recombinant nucleic acid molecules are described. The molecules have a first nucleic acid sequence encoding an antigen containing two or more cytolytic T lymphocyte (CTL) epitopes and analogues thereof which can be recognised by a CD8+ T cell. Peptides encoded by the molecules and vectors and compositions containing these molecules are also described. Methods of eliciting an immune response using these molecules are also described.

L'invention concerne des molécules d'acides nucléiques recombinants. Ces molécules possède une première séquence d'acides nucléiques codant un antigène renfermant au moins deux épitopes de lymphocyte T cytolytique (CTL), lesdits épitopes étant sélectionnés parmi des séquences d'acides aminés SEQ ID NO: 1, 2, 3, 4, 5 et des analogues correspondants qui peuvent être reconnus par une cellule T CD8+ reconnaissant un épitope doté de la séquence d'acides aminés d'une des séquences SEQ ID NO: 1, 2, 3, 4, 5 or 6. Ladite invention a également trait à des peptides codés par les molécules, les vecteurs et les compositions renfermant ces molécules, ainsi que des méthodes permettant de provoquer une réponse immunitaire au moyen de ces molécules.

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