Vaccine composition comprising an antigen and a peptide...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 38/00 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2426490

The invention relates to a vaccine which comprises at least one antigen and a peptide comprising a sequence R1-XZXZNXZX-R2, whereby N is a whole number between 3 and 7, preferably 5, -X is a positively charged natural and/or non- natural amino acid residue, Z is an amino acid residue selected from the group consisting of L, V, I, F and/or W, and R1 and R2 are selected independently are from the other from the group consisting of -H, -NH2, -COCH3, -COH, a peptide with up to 20 amino acid residues or a peptide reactive group or a peptide linker with or without a peptide; X-R2 may also be an amide, ester or thioester of the C-terminal amino acid residue, as well as the use of said peptide for the preparation of an adjuvant for enhancing the immune response to at least one antigen.

L'invention concerne un vaccin renfermant au moins un antigène et un peptide comprenant une séquence R¿1?-XZXZ¿N?XZX-R¿2?, dans laquelle N est un nombre entier compris entre 3 et 7, de préférence 5, X est un résidu d'acide aminé naturel et/ou non naturel à charge positive, Z est un résidu d'acide aminé choisi dans le groupe constitué par L, V, I, F et/ou W, et R¿1? et R¿2? sont choisis indépendamment l'un de l'autre dans le groupe constitué par -H, -NH¿2?, -COCH¿3?, -COH, un peptide comprenant jusqu'à 20 résidus d'acide aminé, un groupe réactif peptidique ou un liant peptidique avec ou sans peptide, X-R¿2? pouvant également être un amide, un ester ou un thioester du résidu d'acide aminé C-terminal. L'invention concerne également l'utilisation de ce peptide pour la préparation d'un adjuvant destiné à augmenter la réponse immunitaire vis-à-vis d'un antigène au moins.

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