A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/295 (2006.01) A61K 47/02 (2006.01)
Patent
CA 2455406
The invention concerns a vaccine composition comprising two valences; (i) a first valence which is adjuvant-enhanced with aluminium hydroxide and (ii) a second valence which contains a polysaccharide of bacterial capsule comprising one or more -O- acetyl groups and which is not adsorbed with aluminium oxide due to the presence of a protecting compound which may be a phosphate, a citrate or a carbonate and which prevents said adsorption. The first valence can be any vaccine valence. In one particular embodiment, the vaccine composition contains (i) the Hepatite A valence, adsorbed on aluminium hydroxide and (ii) the typhoid fever valence formed by the polysaccharide Vi of the Salmonella typhi capsule.
L'invention a pour objet une composition vaccinale comprenant au moins deux valences; (i) une première valence qui est adjuvantée avec de l'hydroxyde d'aluminium et (ii) une deuxième valence qui contient un polysaccharide de capsule bactérienne comportant un ou des groupements O-acétyls et qui n'est pas adsorbée sur l' hydroxyde aluminium en raison de la présence d'un composé protecteur qui peut être un phosphate, un citrate ou encore un carbonate et qui empêche cette adsorption. La première valence peut être n'importe quelle valence vaccinale. Selon un mode particulier, la composition vaccinale comprend (i) la valence Hépatite A, adsorbée sur hydroxyde d'aluminium et (ii) la valence fièvre typhoïde constituée par du polysaccharide Vi de la capsule de Salmonella typhi.
Aventis Pasteur
Robic
LandOfFree
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