Vaccine composition containing polyribosylribitol phosphate...

A - Human Necessities – 61 – K

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Details

A61K 39/385 (2006.01) A61K 39/08 (2006.01) A61K 39/102 (2006.01) A61K 39/116 (2006.01) A61K 39/295 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2218764

A vaccine composition containing one or more antigens comprising the high molecular weight capsular polysaccharide of type b Haemophilus influenza, or polyribosylribitol phosphate, coupled to the tetanus toxoid and an aluminium-based adjuvant, wherein the aluminium-based adjuvant has, in its natural state, or following anion addition, a zero point of charge of less than about 7.2. A method for making said vaccine composition is also described.

L'invention concerne une composition vaccinale comprenant au moins un antigène constitué par le polysaccharide capsulaire de Haemophilus influenzae type b ou Polyribosylribitol Phosphate à haut poids moléculaire couplé à l'anatoxine tétanique ainsi qu'un adjuvant à base d'aluminium, dans lequel l'adjuvant à base d'aluminium présente par nature ou après addition d'anions un point de charge zéro inférieur à environ 7,2. L'invention à également pour objet un procédé de fabrication d'une telle composition vaccinale.

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