Vaccine composition containing transforming growth factor alpha

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/18 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 14/495 (2006.01)

Patent

CA 2430621

The invention relates to a vaccine composition capable of producing a specific immune response against autologous TGF alpha, which contains TGF alpha or any derivative thereof and active ingredients and an appropriate adjuvant. The vaccine preparation can also include a combination of TGF alpha and other growth factors such as epidermic growth factor (EGF) in such a way that it inhibits the proliferation of tumors whose progression depends on said factors. The growth and proliferation of epidermoid carcinomas can be controlled with the use of said composition.

La présente invention concerne le domaine de l'immunologie et de la médecine humaine, en particulier l'immunothérapie active spécifique aux tumeurs malignes dont la croissance dépend du TGF.alpha., également utilisée dans le traitement d'autres maladies dépendant du TGF.alpha., à l'aide d'une préparation de vaccin pouvant provoquer une réaction d'immunocastration du TGF.alpha. autologue. L'invention concerne également l'obtention d'une préparation de vaccin comprenant une combinaison du TGF.alpha. et d'autres ligands du EGF-R, tels que le facteur de croissance épidermique (EGF), pouvant inhiber la prolifération des tumeurs dont la progression dépend de ces facteurs de croissance. On prévient ainsi l'éventuelle résistance de la tumeur à des vaccins contenant chacune de ces molécules séparément.

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