A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61P 31/10 (2006.01) A61P 37/04 (2006.01) C12N 15/113 (2010.01) C07K 14/37 (2006.01)
Patent
CA 2755273
The present invention provides therapeutic compositions and methods for treating and preventing fungal disease or conditions including mucormycosis. The therapeutic methods and compositions of the invention include vaccine compositions having an FTR polypeptide or an antigenic fragment of the polypeptide; a vector including a nucleotide sequence that is substantially complimentary to at least 18 contiguous nucleotides of FTR sequence; an antisense; a small interfering RNA or an antibody inhibitor of FTR. The vaccine compositions of the invention can further include an adjuvant.
La présente invention concerne des compositions thérapeutiques et des procédés pour traiter ou prévenir une maladie ou des affections fongiques comprenant la mucormycose. Les procédés thérapeutiques et les compositions de l'invention comprennent des compositions de vaccin ayant un polypeptide FTR ou un fragment antigénique du polypeptide; un vecteur comprenant une séquence nucléotidique qui est sensiblement complémentaire d'au moins 18 nucléotides contigus de séquence FTR; un antisens; un petit ARN interférant ou un anticorps inhibiteur de FTR. Les compositions de vaccin de l'invention peuvent comprendre en outre un adjuvant.
Edwards John E.
Fu Yue
Ibrahim Ashraf S.
Spellberg Brad J.
Los Angeles Biomedical Research Institute At Harbor-Ucla Medical
Osler Hoskin & Harcourt Llp
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