Vaccine compositions containing amyloid beta1-6 antigen arrays

A - Human Necessities – 61 – K

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Details

A61K 39/385 (2006.01) A61K 39/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2492930

The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an A.beta.1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one A.beta. 1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

La présente invention se rapporte aux domaines de la biologie moléculaire, de la virologie, de l'immunologie et de la médecine. L'invention concerne une composition contenant une matrice d'antigènes ou de chromosomes antigéniques ordonnés et répétitifs, et plus particulièrement, une composition VLP peptidique A.beta.1-6. L'invention concerne plus précisément une composition renfermant une particule virale et au moins un peptide A.beta.1-6 lié à celle-ci. L'invention concerne en outre un procédé d'obtention des conjugués et des matrices ordonnées et répétitives, respectivement. Les compositions de cette invention sont utilisées dans la production de vaccins pour le traitement de la maladie d'Alzheimer et comme pharmaceutique afin d'éviter ou de soigner la maladie d'Alzheimer et d'induire efficacement les réponses immunitaires, notamment les réponses des anticorps. Les compositions de cette invention se prêtent particulièrement à l'induction efficace de réponses immunitaires autospécifiques dans le contexte indiqué.

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