Vaccine compositions obtained from streptomyces

Details Vaccine compositions obtained from streptomyces Vaccine compositions obtained from streptomyces

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/04 (2006.01) A61P 15/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2559633

The invention relates to the field of immunology and, more specifically, to the control of infectious diseases caused by microbacteria, which is based on the use of vaccines for the prevention of said diseases. The inventive vaccines have been developed with the use of live strains of Streptomyces, which may or may not express antigens of M. tuberculosis, and have demonstrated their protective capacity against the threat of BCG and M. tuberculosis after being administered by different routes. The invention also relates to the use of strains of Streptomyces for the expression of heterologous antigens of vaccinal interest.

L'invention concerne le domaine de l'immunologie, en particulier la lutte contre les maladies infectieuses provoquées par des mycobactéries, fondée sur l'utilisation de vaccins pour la prévention de ces maladies. L'invention consiste à développer des vaccins fondés sur l'utilisation de champignons vivants de Streptomyces exprimant ou n'exprimant pas des antigènes de M. tuberculosis, lesquels présentent une activité protectrice contre le BCG et le bacille M. tuberculosis après administration par des voies diverses. L'invention concerne également l'utilisation desdits champignons de Streptomyces pour l'expression d'antigènes hétérologues vaccinaux d'intérêt.

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