A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61P 27/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2550482
A vaccine for preventing formation of blood vessels, for example neoangiogenesis, as well as repressing existing vascularization associated with tumors and other diseases, comprising angiomotin, for example as a whole molecule or fragment thereof or encoded as a gene or mRNA, or administered as dendritic cells (DC cells) expressing angiomotin, which may be utilized to generate immune responses to the angiomotin molecule. Inhibition of angiogenesis and delay in tumor outgrowth in animal models of cancer is achieved.
Vaccin destiné à prévenir la formation de vaisseaux sanguins, par exemple la néoangiogenèse, ainsi qu'à réprimer la vascularisation existante associée à des tumeurs et à d'autres maladies. Ledit vaccin contient de l'angiomotine, par exemple en tant que molécule entière ou fragment de molécule ou codé en tant que gène ou ARNm, ou administré en tant que cellules dendritiques exprimant l'angiomotine, et peut être utilisé pour produire des réponses immunitaires à la molécule d'angiomotine. Ledit vaccin inhibe l'angiogenèse et retarde l'expansion tumorale dans des modèles animaux de cancer.
Holmgren Lars
Kiessling Rolf
Bioinvent International Ab
Borden Ladner Gervais Llp
LandOfFree
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