Vaccine comprising an attenuated pestivirus

Details Vaccine comprising an attenuated pestivirus Vaccine comprising an attenuated pestivirus

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/00 (2006.01) A61K 39/187 (2006.01)

Patent

CA 2561719

The present invention relates to attenuated pestivurses, in particular to attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Erns and at least another mutation in the coding sequence for Npro which preferably leads to combined inactivation of the RNase activity residing in glycoprotein Erns in addition to the inactivation of the (hypothesized) immunemodulating activity residing in Npro.The invention also relates to methods for attenuating pestiviruses such as BVDV, nucleic acids encoding said pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV of the invention.

L'invention se rapporte à des pestivirus atténués, notamment des BVDV atténués, au moins une mutation se trouvant dans la séquence de codage de la glycoprotéine Erns et au moins une autre mutation se trouvant dans la séquence de codage de Npro ce qui entraîne, de préférence, l'inactivation combinée de l'activité de Rnase dans la glycoprotéine Erns en plus de l'inactivation de l'activité d'immunomodulation (hypothétique) de Npro. L'invention se rapporte aussi à des procédés d'atténuation de pestivirus tels que BVDV, à des acides nucléiques codant ces pestivirus, notamment BVDV, à des compositions et des vaccins comprenant les pestivirus atténués, notamment BVDV, de l'invention.

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