Vaccine comprising protein nmbo964 from meisseria meningitidis

Details Vaccine comprising protein nmbo964 from meisseria meningitidis Vaccine comprising protein nmbo964 from meisseria meningitidis

A - Human Necessities

61

K

A61K 39/095 (2006.01) C07K 14/22 (2006.01)

Patent

CA 2735910

The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bactericidal antibodies are generated against said antigen. It has been found for the first time that this antigen's expression is zinc regulated and therefore methods are provided to upregulated expression through removal of the zinc repression mechanism of the cell or promoter, or through removal of zinc from the culture medium.

La présente invention concerne des compositions immunogènes comprenant des vésicules causées par Neisseria avec des taux régulés à la hausse des antigènes NMB0964 de sorte que des anticorps bactéricides soient générés contre ledit antigène. Il a été découvert pour la première fois que lexpression de cet antigène est régulée par le zinc et, par conséquent, la présente invention concerne des procédés pour lexpression régulée à la hausse par élimination du mécanisme de répression du zinc de la cellule ou du promoteur, ou par élimination du zinc dans le milieu de culture.

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