Vaccine delivery compositions and methods of use

A - Human Necessities – 61 – K

Patent

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A61K 39/00 (2006.01)

Patent

CA 2595783

The present invention provides synthetic vaccine delivery compositions based on polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU) polymers for stimulating an immune response to a variety of pathogenic organisms and tumor cells in humans and other mammals. The vaccine delivery compositions are formulated as a liquid dispersion of polymer particles or molecules including class I or class II antigen peptides derived from organism or tumor cell proteins, which are taken up by antigen presenting cells of the mammal to induce an immune response in the mammal. Methods of inducing an immune response to the pathogenic organism or tumor cells in the invention compositions are also included.

L'invention concerne des compositions de synthèse pour l'administration de vaccins, à base de polymères de polyesteramide (PEA), de polyesteruréthane (PEUR) et de polyester-urée (PEU) pour stimuler une réponse immunitaire à une série d'organismes pathogènes et de cellules tumorales chez les humains et les mammifères. Ces compositions d'administration de vaccins sont formulées sous forme de dispersion liquide de particules ou de molécules polymères contenant des peptides antigènes de classe I ou de classe II dérivés de protéines de l'organisme ou de la cellule tumorale, ces protéines étant retenues par des cellules du mammifère présentant un antigène pour induire une réponse immunitaire dans le mammifère. La présente invention porte également sur des procédés pour induire une réponse immunitaire à un organisme pathogène ou à des cellules tumorales dans les compositions de l'invention.

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