Vaccine delivery compositions and methods of use

Details Vaccine delivery compositions and methods of use Vaccine delivery compositions and methods of use

A - Human Necessities

61

K

A61K 47/34 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) A61K 39/21 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2676601

The present invention provides synthetic vaccines against a variety of pathogenic organisms and tumor cells in humans and other mammals based on biodegradable polymers containing polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU) and immunostimulatory adjuvants. The vaccines can be formulated as a liquid dispersion of polymer particles or molecules in which are dispersed an immunostimulatory adjuvant, such as a TLR agonist, and whole protein or peptidic antigens containing MHC class I or class II epitopes derived from organism or tumor cell proteins. Methods of inducing an immune response via intracellular mechanisms to the pathogenic organism or tumor cells specific for the antigen in the invention compositions are also included.

La présente invention concerne des vaccins synthétiques contre une multitude d'organismes pathogènes et des cellules cancéreuses chez des humains et autres mammifères, reposant sur des polymères biodégradables contenant du polyesteramide (PEA), du polyesteruréthane (PEUR), et de la polyester-urée (PEU) et des adjuvants immunostimulants. Les vaccins peuvent être composés sous la forme d'une dispersion liquide de particules polymères ou de molécules dans laquelle sont dispersés un adjuvant immunostimulant, tel qu'un agoniste de TLR, et des antigènes protéiniques ou peptidiques entiers contenant des épitopes MHC classe I ou classe II dérivés de protéines de cellules cancéreuses ou d'organismes. L'invention concerne également des procédés d'induction d'une réponse immunitaire via des mécanismes intracellulaires à un organisme pathogène ou à des cellules cancéreuses spécifiques à l'antigène entrant dans les compositions de l'invention.

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