Vaccine for active immunization containing hepatitis b...

Details Vaccine for active immunization containing hepatitis b... Vaccine for active immunization containing hepatitis b...

A - Human Necessities

61

K

167/130

A61K 39/12 (2006.01) C07K 14/02 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1066190

VACCINE FOR ACTIVE IMMUNIZATION CONTAINING HEPATITIS B SURFACE ANTIGEN AND ASSOCIATED ANTIGEN Abstract of the Disclosure A vaccine against viral hepatitis comprising: A. Antigenic particles having a particle size in the range of 30 to 50 nanometers, said antigenic particles containing hepatitis B surface antigens; B. Said antigen having less than 10 units of free antibody to hepatitis B surface antigens per 1,000 units of hepatitis B surface antigens; C. At least 5% of the particles of said vaccine in the size range of 30 to 50 nanometers containing the hepatitis B surface antigenic specificity(s) which have been termed "e-antigen"; D. Said hepatitis B surface antigens, including e-antigens, being present in said vaccine in an amount sufficient to produce antibodies when introduced into a host animal, the balance being a medium which is physiologically acceptable, especially to humans and primates.

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