Vaccine for congenital tremors in pigs

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/40 (2006.01) A61K 39/12 (2006.01) C07K 14/01 (2006.01) C07K 16/08 (2006.01) C12N 7/00 (2006.01) C12N 7/02 (2006.01) C12N 15/33 (2006.01) C12P 21/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2410229

The invention is based on the cloning of porcine circovirus (PCV) strains from pigs with congenital tremors. These results provide a first step for the development of diagnostic and therapeutic applications for congenital tremors in a pig. The diagnostic method comprises determining whether the pig has been infected by a porcine circovirus strain of type 1 or type 2. The invention further provides a method for the prevention or treatment of congenital tremors in a pig, which method comprises administering to the pig an effective amount of an immunogenic PCV 1 or PCV 2 polypeptide or of a nucleic acid encoding this polypeptide. Another subject of the invention is the new PCV nucleic acid sequences identified by the inventors and the polypeptides encoded by these sequences, as well as the new PCV isolates and immunogenic preparations thereof.

La présente invention repose sur le clonage de souches du circovirus porcin (CVP) provenant de porcs atteints de tremblements congénitaux. L'invention constitue une première étape dans la mise au point d'applications diagnostiques et thérapeutiques destinées à traiter les tremblements congénitaux chez les porcs. Le procédé diagnostique de l'invention consiste à déterminer si le porc a été infecté par une souche de circovirus porcin de type 1 ou de type 2. L'invention concerne également un procédé permettant de traiter ou de prévenir les tremblements congénitaux chez le porc, selon lequel on administre au porc une quantité efficace d'un polypeptide immunogène de CVP1 ou CVP2 ou d'un acide nucléique codant ledit polypeptide. L'invention concerne également de nouvelles séquences d'acide nucléique du CVP qui ont été identifiées par les inventeurs et les polypeptides codés par ces séquences, ainsi que de nouveaux isolats de CVP et des préparations immunogènes fabriquées à partir de ces derniers.

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