Vaccine for diarrhea caused by e. coli

A - Human Necessities – 61 – K

Patent

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167/135

A61K 39/07 (2006.01) A61K 39/108 (2006.01) A61K 39/116 (2006.01)

Patent

CA 1139663

ABSTRACT A relatively safe and effective vaccine for coliform diar- rhea and related infections is prepared from semipurified K99 and other concentrated subcellular antigens and organelles of select- ed E. coli strains. For this purpose broth cultures of E. coli bacteria are mechanically sheared or sonicated to disrupt the bacterial cells, then centrifuged and the supernatent containing subcellular particles and components is concentrated by ultra- filtration and sterilized by the addition of a preservative and- /or stabilizer.

350749

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