C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 39/155 (2006.01) C07K 14/135 (2006.01)
Patent
CA 2704153
The present invention is directed to alphavirus vectored vaccine contructs encoding paramyxovirus proteins that find use in the prevention of respiratory syncytial virus or human metapneumo virus infections. In particular, these vaccines induce cellular and humoral immune responses that inhibit RSV. Also disclosed are improved methods for producing alphavirus vectored paramyxovirus vaccines.
La présente invention concerne des constructions de vaccins à vecteurs d'alphavirus codant pour les protéines du paramyxovirus qui peuvent être utilisés dans la prévention des infections causées par le virus respiratoire syncytial (VRS) ou par le virus métapneumonique humain (MPV). En particulier, ces vaccins induisent des réponses immunitaires cellulaires et à médiation humorale qui inhibent le VRS. L'invention concerne également des procédés améliorés de production des vaccins à vecteurs d'alphavirus contre le paramyxovirus.
Crowe James E. Jr.
Davis Nancy L.
Johnston Robert E.
Mok Hoyin
Williams John V.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The University Of North Carolina At Chapel Hill
Vanderbilt University
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