Vaccine for the treatment of osteoarthritis

Details Vaccine for the treatment of osteoarthritis Vaccine for the treatment of osteoarthritis

A - Human Necessities

61

K

A61K 39/00 (2006.01)

Patent

CA 2698920

The present invention pertains to a vaccine for the treatment of osteoarthritis in a vertebrate comprising IL-1 .beta. and optionally TNF-.alpha. cytokines or derivatives thereof, and in association with said IL-1 .beta. and optional TNF-.alpha. or derivatives thereof a part that is non-self with respect to the vertebrate such that the vaccine elicits an immune response in the vertebrate against IL-1 .beta. and TNF-.alpha. self-molecules of the said vertebrate.

La présente invention porte sur un vaccin pour le traitement de l'ostéoarthrite chez un vertébré, comprenant l'interleukine IL-1 ß et, facultativement, les cytokines TNF-a ou des dérivés de celles-ci, ainsi que, associée avec ladite IL-1ß et l'éventuelle TNF-a ou les éventuels dérivés de celle-ci, une partie qui est immunogène chez le vertébré, de telle sorte que le vaccin déclenche chez celui-ci une réponse immunitaire contre les molécules IL-1 ß et TNF-a du soi.

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