Vaccine for transcutaneous immunization against etec-caused...

A - Human Necessities – 61 – K

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A61K 39/108 (2006.01) A61K 39/015 (2006.01) A61K 39/39 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61P 31/04 (2006.01) A61K 9/00 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2437899

A vaccine delivered by transcutaneous immunization provides an effective treatment against infections by pathogens such as, for example, enterotoxigenic Escherichia coli (ETEC) and/or for symptoms of diarrheal disease caused thereby. For example, one, two, three, four, five or more antigens derived from ETEC and capable of inducing an antigen-specific immune response (e.g., toxins, colonization or virulence factors) and one or more optional adjuvant (e.g., whole bacterial ADP-ribosylating exotoxins, B subunits or toxoids thereof, detoxified mutants and derivatives thereof) are used to manufacture vaccines or to induce systemic and/or mucosal immunity.

L'invention concerne un vaccin d'immunisation administré par voie transcutanée, constituant un traitement efficace contre des infections provoquées par des pathogènes tels que par exemple, Escherichia coli (ETEC) et/ou, pour des symptômes diarrhéiques provoqués par l'ETEC. Par exemple, 1, 2, 3, 4, 5 ou plusieurs antigènes dérivés de l'ETEC et pouvant induire une réponse immunitaire spécifique aux dits antigènes (par exemple, des toxines, des facteurs de colonisation ou de virulence) et un ou plusieurs adjuvants optionnels (par exemple, des exotoxines bactériennes ribolysant de l'ADP, des sous-unités B ou des anatoxines, desdites exotoxines, des mutants détoxiqués et des dérivés desdites exotoxines) sont utilisés afin de fabriquer des vaccins ou d'induire une immunité systémique et/ou des muqueuses.

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