A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 37/08 (2006.01) C07K 7/00 (2006.01) C07K 14/47 (2006.01) C07K 16/42 (2006.01) C07K 16/44 (2006.01)
Patent
CA 2457111
The present invention relates to the provision of novel medicaments for the treatment, prevention or amelioration of allergic disease. In particular, the novel medicaments are epitopes or mimotopes derived from IgE. The novel regions presented may be the target for both passive and active immunoprophylaxis or immunotherapy. The invention further relates to methods for production of the medicaments, pharmaceutical compositions containing them and their use in medicine. Also forming an aspect of the present invention are ligands, especially monoclonal antibodies, which are capable of binding the IgE regions of the present invention, and their use in medicine as passive immunotherapy or immunoprophylaxis.
L'invention concerne de nouveaux médicaments destinés au traitement, à la prévention ou à l'atténuation des allergies. Ces nouveaux médicaments sont notamment des épitopes ou des mimotopes dérivés d'IgE. Les nouvelles régions concernées peuvent servir de cible à l'immunoprophylaxie ou à l'immunothérapie, active ou passive. L'invention concerne également des procédés de préparation de médicaments, des compositions pharmaceutiques les contenant et leur utilisation en médecine. L'un des aspects de la présente invention couvre des ligands, notamment des anticorps monoclonaux, qui sont capables de lier les régions IgE selon la présente invention, et leur utilisation en médecine en immunoprophylaxie passive ou en immunothérapie passive.
Acambis Research Limited
Glaxosmithkline Biologicals S.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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