Vaccine preparations containing attenuated toxin

Details Vaccine preparations containing attenuated toxin Vaccine preparations containing attenuated toxin

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 39/012 (2006.01) A61K 39/015 (2006.01) A61K 39/02 (2006.01) A61K 39/07 (2006.01) A61K 39/10 (2006.01) A61K 39/108 (2006.01) A61K 39/116 (2006.01) A61K 39/118 (2006.01) A61K 39/145 (2006.01) A61K 39/15 (2006.01) A61K 39/165 (2006.01) A61K 39/20 (2006.01) A61K 39/21 (2006.01) A61K 39/295 (2006.01) A61P 31/00 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2348658

Described herein are adjuvants containing as the active ingredient an attenuated toxin having a residual activity of at least 1/2000 the activity of the natural toxin and vaccines containing such adjuvants. By using, for example, attenuated natural cholera toxin, vaccines capable of showing sufficient immune potentiation in percutaneous vaccination or nasal vaccination can be presented.

Adjuvant contenant en tant qu'ingrédient actif une toxine atténuée ayant une activité résiduelle de 1/2000 ou moins que l'activité de la toxine naturelle, et vaccins contenant cet adjuvant. L'utilisation, par exemple, de toxines de choléra naturelles atténuées permet d'obtenir des vaccins capables de produire une augmentation suffisante de l'effet immunitaire lors de la vaccination percutanée ou de la vaccination nasale.

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