Vaccine therapy for choroidal neovascularization

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 38/08 (2006.01) A61P 9/10 (2006.01) A61P 27/02 (2006.01) C07K 14/71 (2006.01)

Patent

CA 2678432

It is tried to determine the presence or absence of the effectiveness of the vaccination with a VEGFR-2-derived peptide which is known as one of the proteins involved in neovascularization by administering the peptide to a model mouse capable of expressing human HLA-A*0201 (an A2/Kb transgenic mouse). As a result, it is found that a vaccine containing the peptide as an antigen is effective on the inhibition of the neovascularization in a choroid. Thus, disclosed is a vaccine for the treatment or prevention or both of a disease induced by the neovascularization in a choroid (neovascular maculopathy), which comprises a VEGFR-2-derived peptide as an active ingredient.

La présente invention concerne l'essai de déterminer la présence ou l'absence de l'efficacité de la vaccination avec un peptide dérivé du VEGFR-2 qui est connu en tant qu'une des protéines impliquées dans la néovascularisation en administrant le peptide à une souris de modèle capable de présenter le HLA-A*0201 humain (une souris transgénique A2/Kb). Par conséquent, il est découvert qu'un vaccin contenant le peptide en tant qu'antigène est efficace sur l'inhibition de la néovascularisation dans une choroïde. Ainsi, la présente invention concerne un vaccin destiné au traitement ou à la prévention ou les deux d'une maladie induite par la néovascularisation dans une choroïde (maculopathie néovasculaire), qui comprend un peptide dérivé du VEGFR-2 en tant qu'ingrédient actif.

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