Vaccine to control equine protozoal myeloencephalitis in horses

Details Vaccine to control equine protozoal myeloencephalitis in horses Vaccine to control equine protozoal myeloencephalitis in horses

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) C07H 21/02 (2006.01) C07K 1/00 (2006.01) C07K 14/00 (2006.01) C07K 14/44 (2006.01) C07K 16/20 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2382026

The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against Sarcocystis neurona. In particular, the present invention provides vaccines that provide active immunity which comprise a polypeptide or DNA vaccine that contains or expresses at least one epitope of an antigen that has an amino acid sequence substantially similar to a unique 16 (+/-4) kDa antigen and/or 30 (+/-4) kDa antigen of Sarcocystis neurona. The present invention further provides a vaccine that provides passive immunity to Sarcocystis neurona comprising polyclonal or monoclonal antibodies against at least one epitope of an antigen substantially similar to a unique 16 (+/-4) kDa antigen and/or 30 (+/-4) kDa antigen of Sarcocystis neurona.

La présente invention concerne des vaccins et des procédés pour fabriquer des vaccins qui protègent de manière passive ou active un équidé (ou tout autre animal) contre Sarcocystis neurona. L'invention concerne notamment des vaccins qui confèrent à l'animal une immunité active et comprennent un vaccin à base de polypeptides ou d'ADN qui contient ou exprime au moins un épitope d'un antigène qui comporte une séquence d'acides aminés sensiblement similaire à un antigène unique de 16 (+/-4) kDa et/ou à un antigène de 30 (+/-4) kDa de Sarcocystis neurona. L'invention concerne en outre un vaccin qui confère à l'animal une immunité passive à Sarcocystis neurona et comprend des anticorps polyclonaux ou monoclonaux contre au moins un épitope d'un antigène sensiblement similaire à un antigène unique de 16 (+/-4) kDa et/ou à un antigène de 30 (+/-4) kDa de Sarcocystis neurona.

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