Vaccine to prevent streptococcal endocarditis

Details Vaccine to prevent streptococcal endocarditis Vaccine to prevent streptococcal endocarditis

A - Human Necessities

61

K

A61K 39/09 (2006.01) C07K 14/315 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2258011

FimA proteins from streptococci and enterococci, which are responsible for bacterial adherence to damaged heart tissue, are potent vaccines against a patient developing endocarditis. Recombinantly produced FimA proteins from S. parasanguis provide protection against S. parasanguis derived endocarditis, as well as endocarditis derived from several other streptococci. Conserved DNA regions in viridans streptococci and enterococci suggest that FimA from these strains will be broadly applicable as a vaccine.

Les protéines Fim A provenant des streptocoques et des entérocoques, qui sont responsables de l'adhérence bactérienne aux tissus cardiaques endommagés, sont de puissants vaccins contre l'endocardite, empêchant cette maladie de se développer chez un patient. Des protéines Fim A produites par recombinaison et provenant de S. parasanguis confèrent une protection contre l'endocardite dérivée de S. parasanguis ainsi que l'endocardite dérivée de plusieurs autres streptocoques. Des régions d'ADN préservées dans les entérocoques et les streptocoques viridians suggèrent que les protéines Fim A provenant de ces souches seront applicables de manière généralisée comme un vaccin.

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