C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2485816
The present invention relates to the novel nucleic acid constructs, useful in nucleic acid vaccination protocols for the treatment and prophylaxis of MUC-1 expressing tumours. In particular, the nucleic acid is DNA and the DNA constructs comprise a gene encoding a MUC-1 derivative having less than 10 perfect repeat units. The invention further provides pharmaceutical compositions comprising said constructs, particularly pharmaceutical compositions adapted for particle mediated delivery, methods for producing them, and their use in medicine. Novel proteins encoded by the nucleic acid and pharmaceutical compositions containing them are also provided.
La présente invention concerne de nouveaux construits d'acide nucléique qui conviennent pour des protocoles de vaccination à base d'acide nucléique destinée au traitement et à la prophylaxie de tumeurs exprimant MUC-1. Plus particulièrement cet acide nucléique est un ADN et ces construits d'ADN comprennent un gène codant pour un dérivé de MUC-1 possédant moins de 10 unités de répétition parfaite. Cette invention concerne aussi des compositions pharmaceutiques comprenant ces construits, en particulier des compositions pharmaceutiques conçues pour un apport via une particule, des techniques de production de ces compositions et l'utilisation de celles-ci dans la médecine. Cette invention concerne enfin de nouvelles protéines codées par cet acide nucléique et des compositions pharmaceutiques contenant ces protéines.
Burden Neil
Ellis Jonathan Henry
Hamblin Paul A.
Glaxo Group Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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