Vaccines against avian herpes viruses

Details Vaccines against avian herpes viruses Vaccines against avian herpes viruses

C - Chemistry, Metallurgy

12

N

167/104, 530/13,

C12N 15/38 (2006.01) A61K 39/245 (2006.01) A61K 39/255 (2006.01) C07K 14/03 (2006.01) C07K 14/055 (2006.01) C12N 9/02 (2006.01) C12N 9/12 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12N 15/869 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1341308

A vaccine effective against Marek's disease virus (MDV) comprises (a) an MDV attenuated by virtue of being TK- or (b) a host expressing an MDV antigen, namely the respective MDV homologues of the HSV gB, gC, gD or gH glycoproteins (or antigenic parts thereof) or the respective MDV homologues of the HSV-1 immediate early genes IE-68 or IE-175. The host may be a herpes virus of turkeys (HVT), more particularly HVT in which the MDV antigen is inserted in the HVT homologue of the HSV gC gene, the ribonucleotide reductase (large subunit) gene or the thymidine kinase (TK) gene.

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