C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 39/08 (2006.01) C07K 14/33 (2006.01) C12N 1/21 (2006.01) C12N 15/00 (2006.01) C12N 15/62 (2006.01) C12N 15/74 (2006.01) C12N 1/36 (2006.01)
Patent
CA 2733425
Attenuated microorganisms expressing Clostridium difficile antigen(s), and methods of using the same for vaccination of patients are disclosed The invention provides an attenuated microorganism expressing an immunogenic portion of a C difficile Toxin A C-terminal repeat region and/or a C difficile Toxin B C-terminal repeat region The microorganism is an attenuated Salmonella comprising an integrated gene expression cassette that directs the expression of the immunogenic peptide from an in vivo inducible promoter.
L'invention concerne des micro-organismes atténués exprimant un ou des antigènes de Clostridium difficile, et des procédés d'utilisation de ceux-ci pour la vaccination de patients. L'invention fournit un micro-organisme atténué exprimant une partie immunogène d'une zone de répétition à terminaison C de toxine A de C difficile et/ou d'une zone de répétition à terminaison C de toxine B de C difficile. Le micro-organisme est une salmonelle atténuée comprenant une cassette d'expression génétique intégrée qui dirige l'expression du peptide immunogène depuis un promoteur pouvant être induit in vivo.
Caproni Lisa
Telfer Jonathan Lewis
Deeth Williams Wall Llp
Emergent Biosolutions Inc.
Emergent Product Development Uk Limited
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