Vaccines against group c neisseria meningitidis

Details Vaccines against group c neisseria meningitidis Vaccines against group c neisseria meningitidis

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 39/095 (2006.01) A61K 39/385 (2006.01) A61K 39/40 (2006.01) C07K 16/12 (2006.01)

Patent

CA 2142981

An immunogenic conjugate comprising a modified group C meningococcal polysaccharide (GCMP) coupled to a carrier molecule. The GCMP is modified by O-deacetylation to a varying extent. This modified GCMP conjugate stimulates a strong im-munogenic response. The antiserum, produced by immunization with this conjugate, is cross-reactive with the native polysaccha-ride. In addition, these antisera elicit a class of antibodies that have potent bactericidal activity.

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