Vaccines against hepatitis c

Details Vaccines against hepatitis c Vaccines against hepatitis c

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01) C07K 14/11 (2006.01) C07K 14/18 (2006.01) C07K 19/00 (2006.01) C12N 15/51 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2222456

A vaccine composition comprises QS21,3 De-O-acylated monophosphoryl lipid A (3D-MPL), an oil in water emulsion, wherein the oil in water emulsion has the following composition: a metabolisible oil, such as squalene, alpha tocopherol and tween 80, and at least one immunogen selected from the group consisting of (a) a hepatitis C virus core protein or an immunogenic derivative thereof, and (b) a hepatitis C virus envelope protein or an immunogenic derivative thereof.

Cette invention concerne un composition de vaccin comprenant: du QS21, un lipide A de monophosphoryle 3 De-O-acétylé (3D-MPL); une émulsion d'huile dans l'eau, l'huile possédant la composition suivante: une huile métabolisable tel que du squalène, du tocophérol alpha et du Tween 80; et, enfin, au moins un immunogène choisi dans le groupe comprenant (a) une protéine de noyau du virus de l'hépatite C ou un de ses dérivés immunogènes, et (b) une protéine d'enveloppe du virus de l'hépatite C ou un de ses dérivés immunogènes.

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