Vaccines against west nile virus

Details Vaccines against west nile virus Vaccines against west nile virus

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 39/12 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2501220

The present invention relates to novel vaccines containing (whole-inactivated) West Nile Viruses and/or West Nile viral proteins derived there from, produced on human cells, wherein the human cells comprise a sequence encoding at least one early region-1 (El) gene product of an adenovirus. The cells are preferably cultured in suspension to very high densities and under serum-free conditions. Herein, it is disclosed that use of such cells results in high titers of West Nile Virus produced.

La présente invention concerne de nouveaux vaccins renfermant des virus du Nil Occidental (complètement inactivés) et/ou des protéines virales dérivées desdits virus du Nil Occidental, produits sur des cellules humaines qui comprennent une séquence codant au moins un produit génique de région 1 précoce (EI) d'un adénovirus. Lesdites cellules sont, de préférence, mises en culture dans une suspension à des densités très élevées et dans des conditions exemptes de sérum. Cette invention a aussi trait au fait que l'utilisation de telles cellules débouche sur des titres élevés du virus du Nil occidental produit.

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