Vaccines and antigenic conjugates

Details Vaccines and antigenic conjugates Vaccines and antigenic conjugates

C - Chemistry, Metallurgy

12

N

C12N 5/12 (2006.01) A61K 39/00 (2006.01) C07K 14/59 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) G01N 33/566 (2006.01) G01N 33/76 (2006.01)

Patent

CA 2145391

A vaccine, useful for fertility control and cancer treatment comprises an antigenic conjugate of a protein reproductive hor- mone, a fragment of such a hormone, or a peptide substantially immunologically equivalent to such a hormone or fragment con- jugated with a chemically-modified diphtheria toxoid, and an adjuvant, both dispersed in an aqueous medium and emulsified with a mixture of oils. An antigenic conjugate which can be used in this or a similar vaccine, comprises a protein reproductive hormone, a fragment of such a hormone, or a peptide substantially immunologically equivalent to such a hormone or fragment, coupled to an epitope peptide having the sequence of at least one T cell lymphocyte epitope of a protein foreign to the animal to be treated with the conjugate, or a sequence substantially immunologically equivalent to such an epitope.

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